TRPM8 ion channels, the primary cold sensors in humans, are activated by innocuous cooling (<28 °C) and cooling compounds (menthol, icilin) and are implicated in sensing unpleasant cold stimuli as well as in mammalian thermoregulation. Overexpression of these thermoregulators in prostate cancer and in other life-threatening tumors, along with their contribution to an increasing number of pathological conditions, opens a plethora of medicinal chemistry opportunities to develop receptor modulators. This Perspective seeks to describe current known modulators for this ion channel because both agonists and antagonists may be useful for the treatment of most TRPM8-mediated pathologies. We primarily focus on SAR data for the different ...
Transient receptor potential melastatin 8 (TRPM8) was originally cloned from prostate tissue. Shortl...
Transient receptor potential melastatin 8 (TRPM8) is a non-selective cation channel activated by col...
Transient receptor potential melastatin 8 (TRPM8) is a non-selective cation channel activated by col...
TRPM8 ion channels, the primary cold sensors in humans, are activated by innocuous cooling (<28 °C) ...
TRPM8 ion channels, the primary cold sensors in humans, are activated by innocuous cooling (<28 °C) ...
TRPM8 ion channels, the primary cold sensors in humans, are activated by innocuous cooling (<28 °C) ...
The transient receptor potential melastatin subtype 8 (TRPM8) is a nonselective, multimodal ion chan...
The transient receptor potential melastatin subtype 8 (TRPM8) is a nonselective, multimodal ion chan...
The transient receptor potential melastatin subtype 8 (TRPM8) is a nonselective, multimodal ion chan...
The transient receptor potential melastatin subtype 8 (TRPM8) is a cold sensor in humans, activated ...
The transient receptor potential melastatin subtype 8 (TRPM8) is a cold sensor in humans, activated ...
The transient receptor potential melastatin subtype 8 (TRPM8) is a cold sensor in humans, activated ...
The transient receptor potential melastatin subtype 8 (TRPM8) is a cold sensor in humans, activated ...
Transient receptor potential melastatin 8 (TRPM8) was originally cloned from prostate tissue. Shortl...
Transient receptor potential melastatin 8 (TRPM8) was originally cloned from prostate tissue. Shortl...
Transient receptor potential melastatin 8 (TRPM8) was originally cloned from prostate tissue. Shortl...
Transient receptor potential melastatin 8 (TRPM8) is a non-selective cation channel activated by col...
Transient receptor potential melastatin 8 (TRPM8) is a non-selective cation channel activated by col...
TRPM8 ion channels, the primary cold sensors in humans, are activated by innocuous cooling (<28 °C) ...
TRPM8 ion channels, the primary cold sensors in humans, are activated by innocuous cooling (<28 °C) ...
TRPM8 ion channels, the primary cold sensors in humans, are activated by innocuous cooling (<28 °C) ...
The transient receptor potential melastatin subtype 8 (TRPM8) is a nonselective, multimodal ion chan...
The transient receptor potential melastatin subtype 8 (TRPM8) is a nonselective, multimodal ion chan...
The transient receptor potential melastatin subtype 8 (TRPM8) is a nonselective, multimodal ion chan...
The transient receptor potential melastatin subtype 8 (TRPM8) is a cold sensor in humans, activated ...
The transient receptor potential melastatin subtype 8 (TRPM8) is a cold sensor in humans, activated ...
The transient receptor potential melastatin subtype 8 (TRPM8) is a cold sensor in humans, activated ...
The transient receptor potential melastatin subtype 8 (TRPM8) is a cold sensor in humans, activated ...
Transient receptor potential melastatin 8 (TRPM8) was originally cloned from prostate tissue. Shortl...
Transient receptor potential melastatin 8 (TRPM8) was originally cloned from prostate tissue. Shortl...
Transient receptor potential melastatin 8 (TRPM8) was originally cloned from prostate tissue. Shortl...
Transient receptor potential melastatin 8 (TRPM8) is a non-selective cation channel activated by col...
Transient receptor potential melastatin 8 (TRPM8) is a non-selective cation channel activated by col...