VRK2 is a Ser-Thr kinase and has two isoforms, cytosolic and nuclear. The full-length VRK2 cytosolic isoform (A) inhibits MAPK signaling by a direct interaction with the corresponding JIP1 or KSR1 scaffold proteins. As a consequence, high levels of VRK2A inhibit in a dose-dependent manner signals mediated by the TAK1-MKK7-JNK in response to hypoxia or interleukin, and the signal of the ERBB2-RAS-RAF-MEK-ERK pathway. Downregulation of VRK2A relieves this inhibition and allows signal transmission in response to stimuli initiated in receptor-tyrosine kinases (RTK), such as ERBB2. Thus, in breast cancer VRK2A and ERBB2 present an inverse correlation.Peer Reviewe
Human vaccinia-related kinases (VRK1 and VRK2) are atypical active Ser-Thr kinases implicated in con...
Background. Cellular biological responses to specific stimulation are determined by a balance among ...
DoctorVaccinia related kinase 3 is a member of the VRK family and is ubiquitously expressed in tissu...
VRK2 is a Ser-Thr kinase and has two isoforms, cytosolic and nuclear. The full-length VRK2 cytosolic...
VRK2 is a Ser-Thr kinase and has two isoforms, cytosolic and nuclear. The full-length VRK2 cyto-soli...
The epidermal growth factor (EGF)–ErbB–mitogen-activated protein kinase (MAPK) transcription signal-...
Resumen del trabajo presentado al 22nd Biennial Congress of the European Association for Cancer Rese...
[ES]La tesis trata los objetivos de: estudiar los patrones de expresión de VRK2 en tejidos normales ...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...
Molecular genetic analysis of VRK1 in mammary epithelial cells: depletion slows proliferation in vit...
During primary tumor progression, mammary epithelial cells lose cell-cell junctions and acquire a me...
DoctorVaccinia-related kinase 2 (VRK2) is an active serine/threonine kinase that is firstly discover...
The spatial and temporal regulation of intracellular signaling is determined by the spatial and temp...
BACKGROUND: Cellular biological responses to specific stimulation are determined by a balance among ...
Therapeutic programmed cell death protein 1 (PD-1) blockade enhances T cell mediated anti-tumor immu...
Human vaccinia-related kinases (VRK1 and VRK2) are atypical active Ser-Thr kinases implicated in con...
Background. Cellular biological responses to specific stimulation are determined by a balance among ...
DoctorVaccinia related kinase 3 is a member of the VRK family and is ubiquitously expressed in tissu...
VRK2 is a Ser-Thr kinase and has two isoforms, cytosolic and nuclear. The full-length VRK2 cytosolic...
VRK2 is a Ser-Thr kinase and has two isoforms, cytosolic and nuclear. The full-length VRK2 cyto-soli...
The epidermal growth factor (EGF)–ErbB–mitogen-activated protein kinase (MAPK) transcription signal-...
Resumen del trabajo presentado al 22nd Biennial Congress of the European Association for Cancer Rese...
[ES]La tesis trata los objetivos de: estudiar los patrones de expresión de VRK2 en tejidos normales ...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...
Molecular genetic analysis of VRK1 in mammary epithelial cells: depletion slows proliferation in vit...
During primary tumor progression, mammary epithelial cells lose cell-cell junctions and acquire a me...
DoctorVaccinia-related kinase 2 (VRK2) is an active serine/threonine kinase that is firstly discover...
The spatial and temporal regulation of intracellular signaling is determined by the spatial and temp...
BACKGROUND: Cellular biological responses to specific stimulation are determined by a balance among ...
Therapeutic programmed cell death protein 1 (PD-1) blockade enhances T cell mediated anti-tumor immu...
Human vaccinia-related kinases (VRK1 and VRK2) are atypical active Ser-Thr kinases implicated in con...
Background. Cellular biological responses to specific stimulation are determined by a balance among ...
DoctorVaccinia related kinase 3 is a member of the VRK family and is ubiquitously expressed in tissu...