HIV-1 reverse transcriptase (RT) genotypes were obtained from 13 patients treated with stavudine. No previously-reported mutations indicative of stavudine resistance were found in these patients and no novel mutations occurred in more than two patients. One patient, treated with stavudine for 1 month and treated previously with zidovudine, zalcitabine and lamivudine, carried a mutation at codon 75 of the RT (V75M). A chimeric virus, including the patient's RT sequence from codon 25 to codon 220, which carried the resistance mutations M41 L, D67N, T69D, K70R, L210W and T215Y in addition to V75M, displayed reduced susceptibility to multiple nucleoside RT inhibitors (NRTIs). Removal of V75M from this RT background resulted in a return of susce...
An extended spectrum of HIV-1 reverse-transcriptase (RT) mutations in HAART-treated patients has b...
We characterized 16 additional mutations in human immunodeficiency virus type 1 (HTV-1) reverse tran...
We characterized 16 additional mutations in human immunodeficiency virus type 1 (HIV-1) reverse tran...
Resistance to nucleoside reverse transcriptase inhibitors (NRTIs) was studied in 527 HIV-1-infected ...
Resistance to nucleoside reverse transcriptase inhibitors (NRTIs) was studied in 527 HIV-1-infected ...
Resistance to nucleoside reverse transcriptase inhibitors (NRTIs) was studied in 527 HIV-1-infected ...
We characterized 16 additional mutations in human immunodeficiency virus type 1 (HIV-1) reverse tran...
We characterized 16 additional mutations in human immunodeficiency virus type 1 (HIV-1) reverse tran...
We characterized 16 additional mutations in human immunodeficiency virus type 1 (HIV-1) reverse tran...
We characterized 16 additional mutations in human immunodeficiency virus type 1 (HIV-1) reverse tran...
We characterized 16 additional mutations in human immunodeficiency virus type 1 (HIV-1) reverse tran...
The World Health Organization Antiretroviral Treatment Guidelines recommend phasing-out stavudine be...
Stavudine administration did not increase the frequency of Y181I/C reverse transcriptase (RT) mutati...
Stavudine administration did not increase the frequency of Y181I/C reverse transcriptase (RT) mutati...
Background The World Health Organization Antiretroviral Treatment Guidelines recommend phasing-out s...
An extended spectrum of HIV-1 reverse-transcriptase (RT) mutations in HAART-treated patients has b...
We characterized 16 additional mutations in human immunodeficiency virus type 1 (HTV-1) reverse tran...
We characterized 16 additional mutations in human immunodeficiency virus type 1 (HIV-1) reverse tran...
Resistance to nucleoside reverse transcriptase inhibitors (NRTIs) was studied in 527 HIV-1-infected ...
Resistance to nucleoside reverse transcriptase inhibitors (NRTIs) was studied in 527 HIV-1-infected ...
Resistance to nucleoside reverse transcriptase inhibitors (NRTIs) was studied in 527 HIV-1-infected ...
We characterized 16 additional mutations in human immunodeficiency virus type 1 (HIV-1) reverse tran...
We characterized 16 additional mutations in human immunodeficiency virus type 1 (HIV-1) reverse tran...
We characterized 16 additional mutations in human immunodeficiency virus type 1 (HIV-1) reverse tran...
We characterized 16 additional mutations in human immunodeficiency virus type 1 (HIV-1) reverse tran...
We characterized 16 additional mutations in human immunodeficiency virus type 1 (HIV-1) reverse tran...
The World Health Organization Antiretroviral Treatment Guidelines recommend phasing-out stavudine be...
Stavudine administration did not increase the frequency of Y181I/C reverse transcriptase (RT) mutati...
Stavudine administration did not increase the frequency of Y181I/C reverse transcriptase (RT) mutati...
Background The World Health Organization Antiretroviral Treatment Guidelines recommend phasing-out s...
An extended spectrum of HIV-1 reverse-transcriptase (RT) mutations in HAART-treated patients has b...
We characterized 16 additional mutations in human immunodeficiency virus type 1 (HTV-1) reverse tran...
We characterized 16 additional mutations in human immunodeficiency virus type 1 (HIV-1) reverse tran...