Correlations between factors determining the pharmacokinetics and antiviral activity of HIV-1 non-nucleoside reverse transcriptase inhibitors of the diaryltriazine and diarylpyrimidine classes of compounds
- Lewi, Paul
- Arnold, Eddy
- Andries, Koen
- Bohets, Hilde
- Borghys, Herman
- Clark, Arthur
- Daeyaert, Frits
- Das, Kalyan
- de Béthune, Marie-Pierre
- de Jonge, Marc
- Heeres, Jan
- Koymans, Luc
- Leempoels, Jos
- Peeters, Jef
- Timmerman, Philip
- Van den Broeck, Walter
- Vanhoutte, Frédéric
- Van't Klooster, Gerben
- Vinkers, Maarten
- Volovik, Yulia
- Janssen, Paul A J
Publication date
January 2004
DOI Publisher
Adis International ISSN
1174-5886 Journal
issn:1179-6901 Citation count (estimate)
17Abstract
To investigate the important factors that determine the bioavailability and the antiviral activity of the diaryltriazine (DATA) and diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitors (NNRTIs) of HIV-1 in animal species and humans using cell-based assays, physicochemical and computed parameters.status: publishe
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