Maternal cytokines and biochemical markers as indicators of moderate and severe preeclampsia

Preeclampsia is considered as a failure of body’s adaptive mechanisms. Maternal immune system is involved in maternal endothelial dysfunction and the subsequent systemic reaction seen in preeclampsia. Further arguments to support the idea of the involvement of the maternal immune system in the development of preeclampsia come from the primipaternity theory. This hypothesis holds that the risk of developing preeclampsia is highest in the first pregnancy, and a previous normal pregnancy is associated with a lowered incidence of preeclampsia in the subsequent pregnancy. Studying production of pro-inflammatory (IL-1β, IL- 8), anti-inflammatory (IL-10), CRP and TNF alpha in moderate and severe preeclampsia in third trimester of pregnancy