Potencial antifertility of Centella asiatica leaf extract

The ideal requirements for contraceptive materials are effective, having minimal side effects, reversible, economical, easily to be used and available. However, no much ideal contraceptive are currently available, so it is necessary to find alternative contraceptive materials in order to gain these criteria. One of the materials is Centella asiatica (L.) Urban). This study aimed to determine the effect of C. asiatica leaf extract on ovarian histology and weight of mice (Mus musculus). This research used a completely randomized design with 5 treatments and 5 replications. 25 of fertile female mice were treated with several doses of C. asiatica leaf extract, 0 (Control), 125 (T1), 200 (T2), 275 (T3) and 350 mg/kg body weight (bw) (T4). Parameters observed were total of primary, secondary and tertiary follicles, corpus luteum, thickness of theca cell and ovarian weight. ANOVA Test and BNT analysis were used to analyze data. Statistical analysis showed that C. asiatica leaf extract affected the ovarian histology and weight of mice. Dose of 275 mg/kg showed the effective treatment that can optimally reduce the number of primary, secondary and tertiary follicles, thickness of theca cells, the number of corpus luteum and mice ovarian weight. Keywords: leaf extract, Centella asiatica, histology, contraception, mic