Sequencing of DISC1 pathway genes reveals increased burden of rare missense variants in schizophrenia patients from a northern Swedish population

Moens, Lotte N
De Rijk, Peter
Reumers, Joke
Van den Bossche, Maarten J A
Glassee, Wim
De Zutter, Sonia
Lenaerts, An-Sofie
Nordin, Annelie
Nilsson, Lars-Göran
Medina Castello, Ignacio
Norrback, Karl-Fredrik
Goossens, Dirk
Van Steen, Kristel
Adolfsson, Rolf
Del-Favero, Jurgen

Open link

Publication date

January 2011

DOI

10.1371/journal.pone.0023450

Publisher

Public Library of Sciene

ISSN

1932-6203

Journal

issn:1932-6203

Citation count (estimate)

Abstract

In recent years, DISC1 has emerged as one of the most credible and best supported candidate genes for schizophrenia and related neuropsychiatric disorders. Furthermore, increasing evidence--both genetic and functional--indicates that many of its protein interaction partners are also involved in the development of these diseases. In this study, we applied a pooled sample 454 sequencing strategy, to explore the contribution of genetic variation in DISC1 and 10 of its interaction partners (ATF5, Grb2, FEZ1, LIS-1, PDE4B, NDE1, NDEL1, TRAF3IP1, YWHAE, and ZNF365) to schizophrenia susceptibility in an isolated northern Swedish population. Mutation burden analysis of the identified variants in a population of 486 SZ patients and 514 control indiv...