Elevation of plasma 1-deoxy-sphingolipids in type 2 diabetes mellitus: a susceptibility to neuropathy?
- Dohrn, M F
- Othman, A
- Hirshman, S K
- Bode, H
- Alecu, I
- Fähndrich, E
- Karges, W
- Weis, J
- Schulz, J B
- Hornemann, T
- Claeys, Kristl
DOIAbstract
Diabetic distal sensorimotor polyneuropathy (DSPN) is a frequent, disabling complication of diabetes mellitus. There is increasing evidence that sphingolipids play a role in insulin resistance and type 2 diabetes (T2DM). Whether neurotoxic 1-deoxy-sphingolipids are elevated in DSPN patients' plasma and whether levels correlate to the DSPN stage were examined.status: publishe
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