Co-localisation analysis of brown adipose deposits on serial 18F-FDG PET/CT scans implies fixed deposits

Purpose: Brown adipose tissue (BAT) is the primary effector organ for non-shivering thermogenesis (NST), which positron emission tomography/computed tomography (PET/CT) studies have shown to be far more prevalent in adult humans than was hitherto believed. Research into weight loss by NST modulation through BAT manipulation requires a reliable imaging biomarker. This study evaluates patterns of BAT uptake on serial PET/CT scans to determine the degree of coincidence over time and the accuracy of PET/CT as a reference standard