Human and mouse enteric nervous system neurosphere transplants regulate the function of aganglionic embryonic distal colon.
- Lindley, Richard
- Hawcutt, Dan
- Connell, Gwen
- Almond, Sarah
- Vannucchi, Maria-Giuliana
- Faussone-Pellegrini, Maria Simonetta
- Edgar, David
- Kenny, Simon
DOIAbstract
Neonatal human gut is a source of ENSPC that can be transplanted to restore the contractile properties of aganglionic bowel by a neurally mediated mechanism. This may aid development of a stem cell-based treatment for Hirschsprung's disease
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