Two-dimensional speckle tracking echocardiography value for the assessment of coronary artery stenosis at rest and during dobutamine stress echocardiography in patients with high probability of coronary artery disease.

The tasks of the research: 1) To determine the diagnostic value of myocardial deformation parameters to predict significant coronary artery stenosis in patients with high probability of CAD. 2) To determine values of left ventricle myocardial deformation parameters, which allows to distinguish significant coronary artery stenosis from non-significant. Methodology of the research: A total of 101 patients, who have high risk for CAD using the Diamond-Forrester criterion. DSE was performed to all patients. Using 2D speckle tracking myocardial deformation parameters were analyzed.78 patients after DSE undergone adenosine magnetic resonanse imaging (AMRI), two groups were formed according to AMRI: non-pathologic (31) and pathologic (44). 75 patients after DSE and AMRI have already undergone coronary artery angiography and two groups were formed — positive (pathologic) \(n=44) and negative (n=31). Results: From BASE to MIN longitudinal and circumferential strain increased in the non-pathologic group, while systolic longitudinal and circumferential SR increased in both groups. Circumferential strain and SR at MIN was lower in the pathologic group. From BASE to MIN early diastolic longitudinal SR increased in both groups, early diastolic circumferential increased only in non-pathologic group. Early diastolic circumferetial SR at MIN and late diastolic radial SR were higher in the non-pathologic group. From MIN to MAX systolic longitudinal SR increased in both groups, late diastolic SR increased in both groups. Conclusion: Important strain and strain: SR – systolic circumferential , early and late diastolic at MIN. At MAX: late diastolic radial. Most sensitive myocardial deformations parameters for coronary artery stenosis assesement are: longitudinal strain at MIN and MAX. Systolic myocardial SR: circumferential at MIN; circumferential at MAX. Diastolic myocardial SR: late radial at MIN; late radial at MAX