Mergaičių, turinčių hiperandrogenizmo simptomų, hormonų kiekis kraujyje ir antropometriniai duomenys

Polycystic ovary syndrome is considered to originate during puberty. The aim of this study was to investigate hormonal status in relationship to anthropometric data in girls with premature adrenarche and adolescent girls with hyperandrogenism, as these conditions are related to polycystic ovary syndrome in adulthood. Materials and methods. 20 girls with premature adrenarche (aged 4.9–10.2 years), 21 postmenarcheal girls with hirsutism (aged 13.3–17.8 years), 2 groups (n=13 in each) of healthy volunteers of similar age and body mass index participated in the study. Results. Serum testosterone and dehydroepiandrosterone sulphate levels were significantly higher in all patients than in controls. Free androgen index and leptin levels were significantly higher, and sex-hormone-binding globulin lower in hirsute adolescents vs. controls. Birth weight standard deviation scores were comparable in all 4 groups. Serum dehydroepiandrosterone sulphate negatively correlated with birth weight standard deviation scores in the group of girls with premature adrenarche (r=–0.57, p