Insulin resistance in diabetes mellitus type 1, and its association with cardiovascular disease.

The aim of the study is to determine frequency of IR, in individuals with type 1 diabetes mellitus and the link between IR and cardiovascular disease. The task of the research is to determine the frequency of insulin resistance among people with T1DM. To determine association between eGDR and age, sex, cardiovascular disease, chronic complications of diabetes. To determine association between IR and duration of disease, BMI, chronic complications of diabetes mellitus, and the dose of insulin. To determine eGDR cutoff value when chronic complications of diabetes are more frequent. To find the association between IR and cardiovascular disease among people with T1DM. Methodology of the research: The study is a part of an international research “Litdiane”. The study involved 200 people, with T1DM, over the age of 18 years. With reference to survey and information from medical records, performed the data analysis. IR is associated with eGDR. It was calculated by the following formula eGDR=24.31-12.22(LKS)-3.29(AH)-0.57(HbA1c%). eGDR was divided into tertiles. The data was considered statistically significant at p < 0,05. Results: Cutoff value of eGDR which shows resistance of insulin is <6,4 mg/kg/min. When eGDR is <6,4 mg/kg/min, diabetic complications were more common. eGDR is lower for patients with chronic complications of diabetes mellitus (p<0,001), and for patients with cardiovascular diseases (5,5 ± 2,4 mg/kg/min (p<0,001)). eGDR has the highest influence on cardiovascular diseases occurrence (p=0.004). Conclusions: Diabetic complications are more common when eGDR is