Clinical study of nonivasive imaging technologies for melanocytic skin tumors

Objective: Evaluate of optical and software testing methods, meaning melanocytes skin tumors (melanoma and pigmented nevus diagnostic) optimization. Tasks: 1) Establish automatic program accuracy of melanoma depth in histological preparation when compared with manual measurement 2) Apply dermatoscopic camera new technology of red and green light filters and to evaluate the added value of cutaneous melanocytic tumor imaging. Methods: In the first stage, operated 41 melanoma and pigmented nevus histological images (tumor depth, pT) measurements were compered according to Breslow, manual and automatic. Automatic pT assessment by a physician pathologist and author of this work used automatic QCapture Pro 7 ™ (QImaging, Canada) program. In the second stage, before surgery 25 cases of pigmented moles was investigate with dermoscopy (x10) “Optomed” (OPTOMED OY LTD, Finland) which is manufacturer of modified red and green light permeable filter. Received visual parameters compared with the morphological characteristics of skin tumors. Results: Comparing automatic and manually measured pT received very high correlation coefficient r = 0.996. It was found a tendency for the green light permeable filter helps to highlight the melanin in the dermis and epidermis, respectively, red light filter – melanophages. Conclusion: 1) Olympus BX43 microscope software enhancements QCapture Pro 7 ™ achieves high accuracy measurement of the depth of skin tumors (PT) when compared with manual measurement. Software pT assessment can be applied in practice as simple and quick information technology.2) Dermoscopy, augmented with green and red filters are easy to manage optical light system, which allows non-invasive way to optimize examination of cutaneous melanocytic neoplasms pigment and vascular changes in architecture