Biologically active compounds of 4-thiazolidinone synthesis, analysis and microbiological testing

Aim of study: to identify potential nifumezine and similar compounds structure- activity relationship. Study methods: antimicrobial activity tests in vitro and prognosis of antimicrobial activity by PASS program. Study results: antimicrobial activity tests in vitro showed that the compouds AM-3 and AM-4 is inactive at concentration 500 µg/ml. Compounds AM-3-1 and AM-4-1 are active against S. aureus, E. faecalis, S. epidermidis. None of the synthesized compounds are not active against P. aeruginosa, P. mirabilis and E. coli. Activity prognosis by PASS program showed that the strongest antibacterial effect predisted compound AM-3-1 and AM-4-1, but these compouds have also the bigest risk to be toxic. Conclusions: it was found that the nitrofuraldehyde in 5-position is important to antimicrobial effects. The position of sulfadimidine (3rd or 4th position)is not significantly affected in rhodanine ring, bet different compounds could be active against different type of bacteria. PASS program can predict the activity of compounds