The new 5-aryliden-4-thiazolidinone-N-amino acids (leucine, tryptophan) and a new 2-acetyl-1-naphthol compound synthesis and antibacterial and antifungal activity assay

The goal: to synthesize new antibacterial and antifungal 5-aryliden-4-thiazolidinone-N-amino acids (leucine, tryptophan) and a new 2-acetyl-1-naphthol compounds and associated substitutions influence on compounds for anti-microbial activity. Objectives: 1. Review the existing literature on bacterial and fungal infections, anti-infection techniques, strategies. 2. Optimize new structures of potential drug searches through computer simulation program, Sybyl - X compounds and biological activity prediction program, PASSonline. 3. Synthesise new 5 - ariliden - thiazolidine - 4 -N - amino acids (leucine, tryptophan) and a new 2-acetyl-1-naphthol compounds. 4. Perform an analysis of the characteristics of compounds using thin layer chromatography, melting temperatures, HPLC, UV, IR spectra methods. 5. Set synthesised compounds of microbial activity against Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus mirabilis, Bacillus subtillis, Bacillus cereus, Candida albicans. Research methods: antimicrobial activity of the compounds were predicted using “PASSonline” and computer molecular modeling program “Sybyl -X 1.1”. Antimicrobial activity was studied “in vitro” rejection method as “poisoned dish method”- bacteria applied on the solution suspending in a Muller - Hinton agar. The results: Synthesised compounds having the widest spectrum of activity with two completely different structures of compounds SBL -1 , SBL -2 and LZL - 19th. Conclusion: It can be argued that Schiff bases synthesized from 2-acetyl-1-naphthol and ketones having 3 carbon atoms in the chain, and 4-thiazolidine-N-amino acid derivatives having substitutes with a nitro group in 5th position of rhodanine ring, has a broad anti-microbial activity