Pituitary adenomas postoperative treatment outcomes: postoperative complications and endocrine outcomes

Author: Martyna Ramančiuckaitė Theme: „Pituitary adenomas postoperative treatment outcomes: postoperative complications and endocrine outcomes“ Pituitary adenomas are benign tumors that constitute approximately 10-15% intracranial and 85-91% of all sellar tumors [1,3]. Recent studies made in the latest year shows surgical treatment of pituitary adenomas outcomes around the world. The aim of this study is to evaluate frequency of postoperative complications and endocrinological outcomes for patients who underwent pituitary adenomas surgery during the period of 2007-2014. We evaluated frequency of endocrinological axis disturbance, estimated postoperative complications and evaluated factors influencing distant postoperative complications occurrence for patients who underwent pituitary adenomas surgery. Methods: The retrospective study evaluated 153 patients who underwent endonasal transsphenoidal surgery during the period 2007-2014. Data were collected from medical records of patients from LHSU Neurosurgery and Endocrinology departments, outpatient units. Presented data was processed and analysed using the statistical package SPSS 20.0. The data has been considered as statistically significant when p1cm) – 118 (77,1 %). We observed 20 (13,07 %) eraly postoperative complications: sinusitis 1(0,7 %), hematoma 5 (3,3 %), meningitis 1 (0,7 %), cerebro spinal fluid leak 8 (5,2 %), hypopituitarism 12 (7,8 %). Mostly postoperative complications occurred after NFPA surgery (12; 7,8 %). During early postoperative period TSH insufficiency was diagnosed in 9 (5,8 %) cases, ACTH in 2 (1,3 %) cases and combined TTH/AKTH insufficiency for 1 (0,65 %) patient (p<0,0001). In the distant postoperative period hypopituitarism was diagnosed for 24 (15,6 %) patients. There were 11 (7,2 %) isolated hormone deficiency cases and 13 (8,5 %) combined. Statistically significant relation was found between hypopituitarism occurrence and sex, most likely hypopituitarism occurred for men (14; 58,3 %) comparing with women(10; 41,7 %) (p<0,03), although between hypopituitarism occurrence and invasion to sphenoid sinuses (p