The meibomian and sebaceous glands secrete lipids to prevent desiccation of the ocular surface and skin, respectively. Precisely how these holocrine tissues regenerate is not well understood. To address this, we characterized keratin 5+ (K5) label-retaining cells (LRCs) and the lineage tracing of keratin 14 (K14) progenitors in mouse meibomian glands. Using the tet-off H2B-GFP/K5tTA mouse, H2B-GFP fluorescence dilutes 2-fold with every division in K5+ cell nuclei after doxycycline administration. In 3D reconstructions generated over a >28-day doxycycline chase, we observed LRCs at the acinus entrance where K6+ ductal epithelium terminates. For lineage tracing, K14CreERT2-Confetti mice were injected intraperitoneally with tamoxifen and eutha...
Mammalian epidermis is a highly dynamic epithelium comprising the interfollicular epidermis, hair fo...
The dynamics and interactions between stem cell pools in the hair follicle (HF), sebaceous gland (SG...
The dynamics and interactions between stem cell pools in the hair follicle (HF), sebaceous gland (SG...
SummaryThe meibomian and sebaceous glands secrete lipids to prevent desiccation of the ocular surfac...
The meibomian and sebaceous glands secrete lipids to prevent desiccation of the ocular surface and s...
The meibomian and sebaceous glands secrete lipids to prevent desiccation of the ocular surface and s...
The meibomian and sebaceous glands secrete lipids to prevent desiccation of the ocular surface and s...
SummaryThe dynamics and interactions between stem cell pools in the hair follicle (HF), sebaceous gl...
PurposeThe purpose of this study was to characterize the natural history of meibomian gland morphoge...
Meibomian gland dysfunction (MGD) is frequent with aging and is the primary cause of dry eye disease...
Meibomian glands (MGs) in eyelids (Fig. 1A) are enlarged sebaceous glands connected to hair follicle...
This paper reviews our current understanding of age-related meibomian gland dysfunction (MGD) and th...
SummarySweat glands are abundant in the body and essential for thermoregulation. Like mammary glands...
Transplantation assays suggest that multipotent stem cells maintain the two lineages of the mammary ...
Meibomian gland dysfunction is a leading cause of ocular surface disease. However, little is known a...
Mammalian epidermis is a highly dynamic epithelium comprising the interfollicular epidermis, hair fo...
The dynamics and interactions between stem cell pools in the hair follicle (HF), sebaceous gland (SG...
The dynamics and interactions between stem cell pools in the hair follicle (HF), sebaceous gland (SG...
SummaryThe meibomian and sebaceous glands secrete lipids to prevent desiccation of the ocular surfac...
The meibomian and sebaceous glands secrete lipids to prevent desiccation of the ocular surface and s...
The meibomian and sebaceous glands secrete lipids to prevent desiccation of the ocular surface and s...
The meibomian and sebaceous glands secrete lipids to prevent desiccation of the ocular surface and s...
SummaryThe dynamics and interactions between stem cell pools in the hair follicle (HF), sebaceous gl...
PurposeThe purpose of this study was to characterize the natural history of meibomian gland morphoge...
Meibomian gland dysfunction (MGD) is frequent with aging and is the primary cause of dry eye disease...
Meibomian glands (MGs) in eyelids (Fig. 1A) are enlarged sebaceous glands connected to hair follicle...
This paper reviews our current understanding of age-related meibomian gland dysfunction (MGD) and th...
SummarySweat glands are abundant in the body and essential for thermoregulation. Like mammary glands...
Transplantation assays suggest that multipotent stem cells maintain the two lineages of the mammary ...
Meibomian gland dysfunction is a leading cause of ocular surface disease. However, little is known a...
Mammalian epidermis is a highly dynamic epithelium comprising the interfollicular epidermis, hair fo...
The dynamics and interactions between stem cell pools in the hair follicle (HF), sebaceous gland (SG...
The dynamics and interactions between stem cell pools in the hair follicle (HF), sebaceous gland (SG...