Immunosuppressive agents in adult kidney transplantation in the NHS: a model-based economic evaluation

This is the author accepted manuscript. The final version is available from OUP via the DOI in this record.Background Immunosuppression is required in kidney transplantation to prevent rejection and prolong graft survival. We conducted an economic evaluation to support the National Institute for Health and Care Excellence in developing updated guidance on the use of immunosuppression, incorporating new immunosuppressive agents, and addressing changes in pricing and the evidence base. Methods A discrete-time state transition model was developed to simulate adult kidney transplant patients over their lifetime. Sixteen different regimens were modelled to assess the cost-effectiveness of basiliximab and rabbit anti-thymocyte globulin (rabbit ATG) as induction agents (with no antibody induction as a comparator), and immediate-release tacrolimus, prolonged-release tacrolimus, mycophenolate mofetil, mycophenolate sodium, sirolimus, everolimus and belatacept as maintenance agents (with ciclosporin and azathioprine as comparators). Graft survival was extrapolated from acute rejection rates, graft function and post-transplant diabetes rates, all estimated at 12 months post-transplantation. NHS and personal social services costs were included. Cost-effectiveness thresholds of £20,000 and £30,000 per quality-adjusted life year (QALY) were used. Results Basiliximab was predicted to be more effective and less costly than rabbit ATG and induction without antibodies. Immediate-release tacrolimus and mycophenolate mofetil were cost-effective as maintenance therapies. Other therapies were either more expensive and less effective, or would only be cost-effective if a threshold in excess of £100,000 per QALY were used. Conclusions A regimen comprising induction with basiliximab, followed by maintenance therapy with immediate-release tacrolimus and mycophenolate mofetil, is likely to be effective for uncomplicated adult kidney transplant patients and a cost-effective use of NHS resources.This project was commissioned by the NIHR HTA programme (project number 09/46/01). Jason Moore has received sponsorship from Astellas Pharma Limited for conference attendance