The involvement of the prefrontal cortex in pain processing has been recently addressed. We studied the role of the infralimbic cortex (IL) and group I metabotropic glutamate receptors (mGluRs) in descending modulation of nociception in control and monoarthritic (ARTH) conditions. Nociception was assessed using heat-induced paw withdrawal while drugs were microinjected in the IL of rats. Local anesthesia of the IL or the adjacent prelimbic cortex (PL) facilitated nociception, indicating that IL and PL are tonically promoting spinal antinociception. Phasic activation with glutamate (GLU) revealed opposing roles of the PL and IL; GLU in the PL had a fast antinociceptive action, while in the IL it had a slow onset pronociceptive action. IL adm...
We examined whether enhanced glutamate release contributes to the expression of persistent spontaneo...
The primary somatosensory cortex (S1) plays a key role in the discrimination of somatic sensations. ...
The role of amygdaloid glutamatergic receptors (GluRs) in maintenance of the sensory versus emotiona...
The involvement of the prefrontal cortex in pain processing has been recently addressed. We studied ...
Dissertação de mestrado em Ciências da SaúdePain arises as a vital defense mechanism, essential for ...
Metabotropic glutamate receptor 5 (mGluR5) activation in the infralimbic cortex (IL) induces pronoci...
International audienceGlutamate plays a key role in modulation of nociceptive processing. This excit...
Plastic changes in the amygdala and limbic cortex networks have been widely shown in chronic pain. W...
Dissertação de mestrado em Ciências da SaúdeIn osteoarthritis (OA) the progressive degeneration of a...
The possible involvement of spinal metabotropic glutamate receptors (mGluRs) were examined in animal...
Metabotropic glutamate receptor 5 (mGluR5) activation in the infralimbic cortex (IL) induces pronoci...
Pain is an essential protective mechanism meant to prevent tissue damages in organisms. On the other...
Metabotropic glutamate receptor (mGluR) 2/3 is distributed in neurons and glial cells in many region...
Metabotropic glutamate receptor 5 (mGluR5) is an excitatory G protein-coupled receptor present in th...
The modulatory actions of glutamate, the main excitatory neurotransmitter in the central nervous sys...
We examined whether enhanced glutamate release contributes to the expression of persistent spontaneo...
The primary somatosensory cortex (S1) plays a key role in the discrimination of somatic sensations. ...
The role of amygdaloid glutamatergic receptors (GluRs) in maintenance of the sensory versus emotiona...
The involvement of the prefrontal cortex in pain processing has been recently addressed. We studied ...
Dissertação de mestrado em Ciências da SaúdePain arises as a vital defense mechanism, essential for ...
Metabotropic glutamate receptor 5 (mGluR5) activation in the infralimbic cortex (IL) induces pronoci...
International audienceGlutamate plays a key role in modulation of nociceptive processing. This excit...
Plastic changes in the amygdala and limbic cortex networks have been widely shown in chronic pain. W...
Dissertação de mestrado em Ciências da SaúdeIn osteoarthritis (OA) the progressive degeneration of a...
The possible involvement of spinal metabotropic glutamate receptors (mGluRs) were examined in animal...
Metabotropic glutamate receptor 5 (mGluR5) activation in the infralimbic cortex (IL) induces pronoci...
Pain is an essential protective mechanism meant to prevent tissue damages in organisms. On the other...
Metabotropic glutamate receptor (mGluR) 2/3 is distributed in neurons and glial cells in many region...
Metabotropic glutamate receptor 5 (mGluR5) is an excitatory G protein-coupled receptor present in th...
The modulatory actions of glutamate, the main excitatory neurotransmitter in the central nervous sys...
We examined whether enhanced glutamate release contributes to the expression of persistent spontaneo...
The primary somatosensory cortex (S1) plays a key role in the discrimination of somatic sensations. ...
The role of amygdaloid glutamatergic receptors (GluRs) in maintenance of the sensory versus emotiona...