Clinical severity and molecular characteristics of circulating and emerging rotaviruses in young children attending hospital emergency departments in France
- Rougemont, A., De
- Kaplon, J.
- Fremy, C.
- Aho, S.
- Pothier, P.
- Legrand-Guillien, M.-C.
- Minoui-Tran, A.
- Payan, C.
- Vabret, A.
- Mendes-Martins, L.
- Chouchane, M.
- Maudinas, R.
- Huet, F.
- Dubos, F.
- Hober, D.
- Lazrek, M.
- Bouquignaud, C.
- Decoster, A.
- Alain, S.
- Languepin, J.
- Gillet, Y
- Lina, B.
- Mekki, Y.
- Morfin-Sherpa, F.
- Guigon, A.
- Guinard, J.
- Foulongne, V.
- Rodiere, M.
- Avettand-Fenoel, V.
- Bonacorsi, S.
- Garbarg-Chenon, A.
- Gendrel, D.
- Lebon, P.
- Lorrot, M.
- Mariani, P.
- Meritet, J.-F.
- Schnuriger, A.
- Agius, G.
- Beby-Defaux, A.
- Oriot, D.
- Colimon, R.
- Lagathu, G.
- Mory, O.
- Pillet, S.
- Pozzetto, B.
- Stephan, J.-L.
DOIAbstract
International audienceGroup A rotavirus (RVA) is the leading cause of acute gastroenteritis in young children worldwide. A prospective surveillance network has been set up to investigate the virological and clinical features of RVA infections and to detect the emergence of potentially epidemic strains in France. From 2009 to 2014, RVA-positive stool samples were collected from 4800 children <5 years old attending the paediatric emergency units of 16 large hospitals. Rotaviruses were then genotyped by RT-PCR with regard to their outer capsid proteins VP4 and VP7. Genotyping of 4708 RVA showed that G1P[8] strains (62.2%) were predominant. The incidence of G9P[8] (11.5%), G3P[8] (10.4%) and G2P[4] (6.6%) strains varied considerably, whereas G4...
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