BACKGROUND: It is widely understood that insulin resistance (IR) critically correlates with the development of liver fibrosis in several types of chronic liver injuries. Several experiments have proved that anti-IR treatment can alleviate liver fibrosis. Sodium-glucose cotransporter 2 (SGLT2) inhibitors comprise a new class of antidiabetic agents that inhibit glucose reabsorption in the renal proximal tubules, improving IR. The aim of this study was to elucidate the effect of an SGLT2 inhibitor on the development of liver fibrosis using obese diabetic Otsuka Long-Evans Tokushima fatty (OLETF) rats and their littermate nondiabetic Long-Evans Tokushima Otsuka (LETO) rats. METHODS: Male OLETF and LETO rats were intraperitoneally injected with ...
Background: Re-evaluation of the subtype of recurrent breast cancer is necessary for deciding the tr...
The regenerating gene (Reg) was isolated originally as a gene specifically over-expressed in regener...
Although recent research showed that advanced glycation endproduct (AGE) and hydroquinone (HQ) are r...
Cholangiocarcinoma (CCA) is associated with high mortality rates because of its resistance to conven...
Hyperglycemia and hyperinsulinemia activate the proliferative potential of hepatic stellate cells (H...
AIM: Renin is a rate-limiting enzyme of the renin-angiotensin system (RAS), and several reports have...
Osteonecrosis of the jaw induced by administration of bisphosphonates (BPs), BP-related osteonecrosi...
Despite the use of various pharmacotherapeutic strategies, fibrosis due to nonalcoholic steatohepati...
Disabled homolog-2 (DAB2) has been reported to be a tumor suppressor gene. However, a number of cont...
Silkworm (Bombyx mori) has an efficient translation system because silkworm can synthesize numerous ...
Molecular targeted therapy with lenvatinib is commonly offered to advanced hepatocellular carcinoma ...
Scope: This study investigated the combined effect of the angiotensin II (AT-II) receptor blocker lo...
Silkworm (Bombyx mori) has an efficient translation system because silkworm can synthesize numerous ...
BACKGROUND: Continuous administration of prostacyclin has improved the survival of patients with p...
A "sono-functional molecule" offers new functions through the structural changes caused by ultrasoni...
Background: Re-evaluation of the subtype of recurrent breast cancer is necessary for deciding the tr...
The regenerating gene (Reg) was isolated originally as a gene specifically over-expressed in regener...
Although recent research showed that advanced glycation endproduct (AGE) and hydroquinone (HQ) are r...
Cholangiocarcinoma (CCA) is associated with high mortality rates because of its resistance to conven...
Hyperglycemia and hyperinsulinemia activate the proliferative potential of hepatic stellate cells (H...
AIM: Renin is a rate-limiting enzyme of the renin-angiotensin system (RAS), and several reports have...
Osteonecrosis of the jaw induced by administration of bisphosphonates (BPs), BP-related osteonecrosi...
Despite the use of various pharmacotherapeutic strategies, fibrosis due to nonalcoholic steatohepati...
Disabled homolog-2 (DAB2) has been reported to be a tumor suppressor gene. However, a number of cont...
Silkworm (Bombyx mori) has an efficient translation system because silkworm can synthesize numerous ...
Molecular targeted therapy with lenvatinib is commonly offered to advanced hepatocellular carcinoma ...
Scope: This study investigated the combined effect of the angiotensin II (AT-II) receptor blocker lo...
Silkworm (Bombyx mori) has an efficient translation system because silkworm can synthesize numerous ...
BACKGROUND: Continuous administration of prostacyclin has improved the survival of patients with p...
A "sono-functional molecule" offers new functions through the structural changes caused by ultrasoni...
Background: Re-evaluation of the subtype of recurrent breast cancer is necessary for deciding the tr...
The regenerating gene (Reg) was isolated originally as a gene specifically over-expressed in regener...
Although recent research showed that advanced glycation endproduct (AGE) and hydroquinone (HQ) are r...