Snapshots of conformational changes of NtrX receiver domain shed light into its signal transduction mechanism
- Fernandez, Ignacio
- Otero, Lisandro Horacio
- Klinke, Sebastian
- Carrica, Mariela del Carmen
- Goldbaum, Fernando Alberto
DOIAbstract
Brucella abortus is an important pathogenic bacterium that has to overcome oxygen deficiency in order to achieve a successful infection. Previously, we proved that a two-component system formed by the histidine kinase NtrY and the response regulator NtrX is essential to achieve an adaptive response to low oxygen tension conditions. Even though the relevance of this signaling pathway has already been demonstrated in other microorganisms, its molecular activation mechanism has not yet been described in detail. In this article, we report the first crystal structures from different conformations of the NtrX receiver domain from B. abortus, and we propose a sequence of events to explain the structural rearrangements along the activation process....
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