A protocol based on cyclocarbonylative Sonogashira reactions has been developed for the synthesis of nitrogen-containing heterocycles. The process is carried out under CO pressure, in the presence of a small amount of PdCl2(PPh3)2 (0.2–0.4 mol-%) as a catalytic precursor, and without the need for a copper salt as cocatalyst. Suitable tosylamides reacted successfully with iodoarenes bearing electron-withdrawing and electron-donating groups. In particular, N-(2-ethynylbenzyl)-4-methylbenzenesulfonamide gave carbonylmethylene isoindolines with complete chemo- and stereoselectivity. On the other hand, the reaction between iodoarenes and N-(2-ethynylphenethyl)-4-methylbenzenesulfonamide did not yield tetrahydroisoquinolines as expected, but dihy...
Cette thèse a principalement porté sur le développement de nouvelles méthodes pour la synthèse d’hét...
La catalyse, les solvants alternatifs et l'économie d'atome font partie des clés pour le développeme...
Cette thèse a principalement porté sur le développement de nouvelles méthodes pour la synthèse d’hét...
A protocol based on cyclocarbonylative Sonogashira reactions has been developed for the synthesis of...
Oxygen and nitrogen heterocycle systems are found in a vast number of natural substrates and biologi...
Oxygen and nitrogen heterocycle systems are found in a vast number of natural substrates and biologi...
The Sonogashira cross-coupling reaction involves the coupling of terminal alkynes with aryl or vinyl...
The isoindolin-1-one moiety has been found in a growing number of naturally occurring compounds, suc...
The isoindolin-1-one moiety has been found in a growing number of naturally occurring compounds, suc...
The isoindolin-1-one moiety has been found in a growing number of naturally occurring compounds, suc...
This thesis has mainly focused on the development of new methods towards the synthesis of highly val...
La catalyse, les solvants alternatifs et l'économie d'atome font partie des clés pour le développeme...
Heterocycles count among many natural products, such as vitamins, hormones, antibiotics, as well as ...
In this study we used a tandem carbonylative Sonogashira reaction/cyclisation process to construct a...
In this work, we present a carbonylative Sonogashira reaction of o-ethynyl benzyl alcohols and aryl ...
Cette thèse a principalement porté sur le développement de nouvelles méthodes pour la synthèse d’hét...
La catalyse, les solvants alternatifs et l'économie d'atome font partie des clés pour le développeme...
Cette thèse a principalement porté sur le développement de nouvelles méthodes pour la synthèse d’hét...
A protocol based on cyclocarbonylative Sonogashira reactions has been developed for the synthesis of...
Oxygen and nitrogen heterocycle systems are found in a vast number of natural substrates and biologi...
Oxygen and nitrogen heterocycle systems are found in a vast number of natural substrates and biologi...
The Sonogashira cross-coupling reaction involves the coupling of terminal alkynes with aryl or vinyl...
The isoindolin-1-one moiety has been found in a growing number of naturally occurring compounds, suc...
The isoindolin-1-one moiety has been found in a growing number of naturally occurring compounds, suc...
The isoindolin-1-one moiety has been found in a growing number of naturally occurring compounds, suc...
This thesis has mainly focused on the development of new methods towards the synthesis of highly val...
La catalyse, les solvants alternatifs et l'économie d'atome font partie des clés pour le développeme...
Heterocycles count among many natural products, such as vitamins, hormones, antibiotics, as well as ...
In this study we used a tandem carbonylative Sonogashira reaction/cyclisation process to construct a...
In this work, we present a carbonylative Sonogashira reaction of o-ethynyl benzyl alcohols and aryl ...
Cette thèse a principalement porté sur le développement de nouvelles méthodes pour la synthèse d’hét...
La catalyse, les solvants alternatifs et l'économie d'atome font partie des clés pour le développeme...
Cette thèse a principalement porté sur le développement de nouvelles méthodes pour la synthèse d’hét...