The possibility of generating neural stem/precursor cells (NPCs) from induced pluripotent stem cells (iPSCs) has opened a new avenue of research that might nurture bench-to-bedside translation of cell transplantation protocols in central nervous system myelin disorders. Here we show that mouse iPSC-derived NPCs (miPSC-NPCs) - when intrathecally transplanted after disease onset - ameliorate clinical and pathological features of experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. Transplanted miPSC-NPCs exert the neuroprotective effect not through cell replacement, but through the secretion of leukaemia inhibitory factor that promotes survival, differentiation and the remyelination capacity of both endogenous oli...
Since multiple sclerosis (MS) is featured with widespread demyelination caused by autoimmune respons...
Using a viral model of the demyelinating disease multiple sclerosis (MS), we show that intraspinal t...
SummaryUsing a viral model of the demyelinating disease multiple sclerosis (MS), we show that intras...
Neural stem cell (NSCs) transplantation is a promising therapy for Multiple Sclerosis (MS). The cli...
Neural stem cell (NSCs) transplantation is a promising therapy for Multiple Sclerosis (MS). The cli...
Multiple sclerosis (MS) is an immune mediated demyelinating disease of the central nervous system (C...
Multiple sclerosis (MS) is an immune mediated demyelinating disease of the central nervous system (C...
Neural stem/precursor cell (NPC) transplantation promotes recovery in experimental autoimmune encep...
Neural stem/precursor cell (NPC) transplantation promotes recovery in experimental autoimmune encep...
Funder: Aston University; doi: http://dx.doi.org/10.13039/501100004950Damage of myelin is a componen...
dissertationNeural precursor cell (NPC) transplantation has emerged as a therapeutic option to treat...
Abstract Background Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central ner...
Murine- and human-induced pluripotent stem cell-derived neural stem/progenitor cells (iPSC-NS/PCs) p...
: Fast remyelination by endogenous oligodendrocyte precursor cells (OPCs) is essential to prevent ax...
SummaryMurine- and human-induced pluripotent stem cell-derived neural stem/progenitor cells (iPSC-NS...
Since multiple sclerosis (MS) is featured with widespread demyelination caused by autoimmune respons...
Using a viral model of the demyelinating disease multiple sclerosis (MS), we show that intraspinal t...
SummaryUsing a viral model of the demyelinating disease multiple sclerosis (MS), we show that intras...
Neural stem cell (NSCs) transplantation is a promising therapy for Multiple Sclerosis (MS). The cli...
Neural stem cell (NSCs) transplantation is a promising therapy for Multiple Sclerosis (MS). The cli...
Multiple sclerosis (MS) is an immune mediated demyelinating disease of the central nervous system (C...
Multiple sclerosis (MS) is an immune mediated demyelinating disease of the central nervous system (C...
Neural stem/precursor cell (NPC) transplantation promotes recovery in experimental autoimmune encep...
Neural stem/precursor cell (NPC) transplantation promotes recovery in experimental autoimmune encep...
Funder: Aston University; doi: http://dx.doi.org/10.13039/501100004950Damage of myelin is a componen...
dissertationNeural precursor cell (NPC) transplantation has emerged as a therapeutic option to treat...
Abstract Background Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central ner...
Murine- and human-induced pluripotent stem cell-derived neural stem/progenitor cells (iPSC-NS/PCs) p...
: Fast remyelination by endogenous oligodendrocyte precursor cells (OPCs) is essential to prevent ax...
SummaryMurine- and human-induced pluripotent stem cell-derived neural stem/progenitor cells (iPSC-NS...
Since multiple sclerosis (MS) is featured with widespread demyelination caused by autoimmune respons...
Using a viral model of the demyelinating disease multiple sclerosis (MS), we show that intraspinal t...
SummaryUsing a viral model of the demyelinating disease multiple sclerosis (MS), we show that intras...