The role of genetic breast cancer susceptibility variants as prognostic factors
- Fasching, Peter A.
- Pharoah, Paul D. P.
- Cox, Angela
- Nevanlinna, Heli
- Bojesen, Stig E.
- Karn, Thomas
- Broeks, Annegien
- Van Leeuwen, Flora E.
- Van't Veer, Laura J.
- Udo, Renate
- Dunning, Alison M.
- Greco, Dario
- Aittomäki, Kristiina
- Blomqvist, Carl
- Shah, Mitul
- Nordestgaard, Børge G.
- Flyger, Henrik
- Hopper, John L.
- Southey, Melissa C.
- Apicella, Carmel
- Garcia Closas, Montserrat
- Sherman, Mark
- Lissowska, Jolanta
- Seynaeve, Caroline
- Huijts, Petra E. A.
- Tollenaar, Rob A. E. M.
- Ziogas, Argyrios
- Ekici, Arif B.
- Rauh, Claudia
- Mannermaa, Arto
- Kataja, Vesa
- Kosma, Veli Matti
- Hartikainen, Jaana M.
- Andrulis, Irene L.
- Ozcelik, Hilmi
- Mulligan, Anna Marie
- Glendon, Gord
- Hall, Per
- Czene, Kamila
- Liu, Jianjun
- Chang Claude, Jenny
- Wang Gohrke, Shan
- Eilber, Ursula
- Nickels, Stefan
- Dörk, Thilo
- Schiekel, Maria
- Bremer, Michael
- Park Simon, Tjoung Won
- Giles, Graham G.
- Severi, Gianluca
- Hooning, Maartje J.
- Martens, John W. M.
- Jager, Agnes
- Kriege, Mieke
- Lindblom, Annika
- Margolin, Sara
- Couch, Fergus J.
- Stevens, Kristen N.
- Olson, Janet E.
- Kosel, Matthew
- Cross, Simon S.
- Balasubramanian, Sabapathy P.
- Reed, Malcolm W. R.
- Miron, Alexander
- John, Esther M.
- Winqvist, Robert
- Pylkäs, Katri
- Jukkola Vuorinen, Arja
- Kauppila, Saila
- Burwinkel, Barbara
- Marme, Frederik
- Schneeweiss, Andreas
- Sohn, Christof
- Chenevix Trench, Georgia
- Lambrechts, Diether
- Dieudonne, Anne Sophie
- Hatse, Sigrid
- Van Limbergen, Erik
- Benitez, Javier
- Milne, Roger L.
- Zamora, M. Pilar
- Pérez, José Ignacio Arias
- Bonanni, Bernardo
- Peissel, Bernard
- Loris, Bernard
- Peterlongo, Paolo
- Rajaraman, Preetha
- Schonfeld, Sara J.
- Anton Culver, Hoda
- Devilee, Peter
- Beckmann, Matthias W.
- Slamon, Dennis J.
- Phillips, Kelly Anne
- Figueroa, Jonine D.
- Humphreys, Manjeet K.
- Easton, Douglas F.
- Schmidt, Marjanka K.
- BAGLIETTO, LAURA
DOIAbstract
Recent genome-wide association studies identified 11 single nucleotide polymorphisms (SNPs) associated with breast cancer (BC) risk. We investigated these and 62 other SNPs for their prognostic relevance. Confirmed BC risk SNPs rs17468277 (CASP8), rs1982073 (TGFB1), rs2981582 (FGFR2), rs13281615 (8q24), rs3817198 (LSP1), rs889312 (MAP3K1), rs3803662 (TOX3), rs13387042 (2q35), rs4973768 (SLC4A7), rs6504950 (COX11) and rs10941679 (5p12) were genotyped for 25 853 BC patients with the available follow-up; 62 other SNPs, which have been suggested as BC risk SNPs by a GWAS or as candidate SNPs from individual studies, were genotyped for replication purposes in subsets of these patients. Cox proportional hazard models were used to test the associa...
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