Germline BRCA1 mutations predispose to breast cancer. To identify genetic modifiers of this risk, we performed a genome-wide association study in 1,193 individuals with BRCA1 mutations who were diagnosed with invasive breast cancer under age 40 and 1,190 BRCA1 carriers without breast cancer diagnosis over age 35. We took forward 96 SNPs for replication in another 5,986 BRCA1 carriers (2,974 individuals with breast cancer and 3,012 unaffected individuals). Five SNPs on 19p13 were associated with breast cancer risk (P trend = 2.3 × 10 9 to P trend = 3.9 × 10 7), two of which showed independent associations (rs8170, hazard ratio (HR) = 1.26, 95% CI 1.17-1.35; rs2363956 HR = 0.84, 95% CI 0.80-0.89). Genotyping these SNPs in 6,800 population-bas...
The 19p13.1 breast cancer susceptibility locus is a modifier of breast cancer risk in BRCA1 mutation...
textabstractGermline mutations in BRCA1 and BRCA2 confer high risks of breast cancer. However, evide...
BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To iden...
Germline BRCA1 mutations predispose to breast cancer. To identify genetic modifiers of this risk, we...
Germline BRCA1 mutations predispose to breast cancer. To identify genetic modifiers of this risk, we...
Recent studies have identified single nucleotide polymorphisms (SNPs) that significantly modify brea...
Recent studies have identified single nucleotide polymorphisms (SNPs) that significantly modify brea...
Background: Genome-wide association studies (GWAS) identified variants at 19p13.1 and ZNF365 (10q21....
textabstractBackground: Genome-wide association studies (GWAS) identified variants at 19p13.1 and ZN...
The 19p13.1 breast cancer susceptibility locus is a modifier of breast cancer risk in BRCA1 mutation...
The 19p13.1 breast cancer susceptibility locus is a modifier of breast cancer risk in BRCA1 mutation...
BACKGROUND: Genome-wide association studies (GWAS) identified variants at 19p13.1 and ZNF365 (10q21....
The 19p13.1 breast cancer susceptibility locus is a modifier of breast cancer risk in BRCA1 mutation...
textabstractGermline mutations in BRCA1 and BRCA2 confer high risks of breast cancer. However, evide...
BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To iden...
Germline BRCA1 mutations predispose to breast cancer. To identify genetic modifiers of this risk, we...
Germline BRCA1 mutations predispose to breast cancer. To identify genetic modifiers of this risk, we...
Recent studies have identified single nucleotide polymorphisms (SNPs) that significantly modify brea...
Recent studies have identified single nucleotide polymorphisms (SNPs) that significantly modify brea...
Background: Genome-wide association studies (GWAS) identified variants at 19p13.1 and ZNF365 (10q21....
textabstractBackground: Genome-wide association studies (GWAS) identified variants at 19p13.1 and ZN...
The 19p13.1 breast cancer susceptibility locus is a modifier of breast cancer risk in BRCA1 mutation...
The 19p13.1 breast cancer susceptibility locus is a modifier of breast cancer risk in BRCA1 mutation...
BACKGROUND: Genome-wide association studies (GWAS) identified variants at 19p13.1 and ZNF365 (10q21....
The 19p13.1 breast cancer susceptibility locus is a modifier of breast cancer risk in BRCA1 mutation...
textabstractGermline mutations in BRCA1 and BRCA2 confer high risks of breast cancer. However, evide...
BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To iden...