Andrew J. Krentz, Lutz Heinemann, Marcus Hompesch (Eds). Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development: A Focus on Early Phase Clinical Studies

Type 2 diabetes mellitus (T2DM) is one of the greatest public health problems worldwide. Adults with T2DM are more likely to have heart diseases or a stroke than adults without diabetes, and cardiovascular diseases account for more than 50% of deaths in T2DM [1]. The risk of macroand microvascular events and mortality are all strongly associated with hyperglycemia, and epidemiological data suggest that an increase of 1% in glycated hemoglobin (HbA1c) corresponds to an increase of approximately 18% in the risk for ..