INVESTIGATION OF C-REACTIVE PROTEIN AND OTHER BLOOD INFLAMMATION MARKERS IN DOGS

The Acute Phase Response (APR) causes the onset of modifications of some blood biochemical and leukocyte parameters. Objectives: Several canine inflammatory markers were investigated. C-reactive protein (CRP) concentrations were considered as elective marker of APR and compared to: i) concentrations of Fibrinogen (Fib), Albumin (Alb), and Iron (Fe); ii) counts of total Leukocyte (WBC), Segmented Neutrophils (NeuSeg), and Band Neutrophils (Band); iii) cytological estimation of Toxic Neutrophils (NeuTOX), Activated Monocytes (MonACT), and Reactive Lymphocytes (LymphREA). Methods: Based on retrospective investigation of CRP concentrations of a Veterinary Teaching Hospital database, two populations were selected: “inflammatory group” with CRP ≥0.30 mg/dL (#1080 samples) and “noninflammatory group” with CRP ≤0.29 mg/dL (#757). Data collected were analysed with MedCalc® software. Results: Dogs belonging to inflammatory group were significantly older (>7 years old) (P<0.05; Relative Risk, 1.38). Low yet significant correlations between CRP and other markers were noted (P