Decreased plasma levels of brain-derived neurotrophic factor (BDNF) during mixed episodes of bipolar disorder
- Piccinni, Armando
- Veltri, Antonello
- Costanzo, Davide
- Vanelli, Federica
- Franceschini, Caterina
- Moroni, Ilenia
- Domenici, Luciano
- Origlia, Nicola
- Marazziti, Donatella
- Akiskal, Hagop Souren
- Dell'Osso, Liliana
Publication date
January 2015
DOI Publisher
Elsevier BV ISSN
0165-0327 Citation count (estimate)
12Abstract
Brain-derived neurotrophic factor (BDNF) is a neurotrophin involved in neurogenesis and neuroplasticity. Decreased blood levels of BDNF have been found during acute manic and depressive states. BDNF has been proposed as a biomarker in illness phases of mood disorders. No information is available regarding BDNF levels during the mixed states of bipolar disorder (BD). The aim of this study was to evaluate BDNF levels during mixed episodes of BD patients and compare them with those of healthy subjects and depressed patients
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