Heuristics for scheduling a two-stage hybrid flow shop with parallel batching machines: application at a hospital sterilisation plant

The model of a two-stage hybrid (or flexible) flow shop, with sequence-independent uniform setup times, parallel batching machines and parallel batches has been analysed with the purpose of reducing the number of tardy jobs and the makespan in a sterilisation plant. Jobs are processed in parallel batches by multiple identical parallel machines. Manual operations preceding each of the two stages have been dealt with as machine setup with standardised times and are sequence-independent. A mixed-integer model is proposed. Two heuristics have been tested on real benchmark data from an existing sterilisation plant: constrained size of parallel batches and fixed time slots. Computation experiments performed on combinations of machines and operator numbers suggest balancing the two stages by assigning operators proportionally to the setup time requirements