Abstract An important role in the regulation of glucose homeostasis is played by incretins, which are gut-derived hormones released in response to nutrient ingestion. In humans, the major incretin hormones are glucagon-like peptide (GLP)-1 and glucose-dependent insulinotropic polypeptide (GIP), and together they fully account for the incretin effect (that is, higher insulin release in response to an oral glucose challenge compared to an equal intravenous glucose load). Studies have shown that GLP-1 and GIP levels and actions may be perturbed in disease states, and the loss of incretin effect is likely to contribute importantly to the postprandial hyperglycaemia in type 2 diabetes. However, the specific cause-effect relationship between dise...
Therapies targeting the action of incretin hormones have been under close scrutiny in recent years. ...
Gastric bypass surgery (GBP), in addition to weight loss, results in dramatic remission of type 2 di...
Gastric bypass surgery (GBP), in addition to weight loss, results in dramatic remission of type 2 di...
Type 2 diabetes (T2D) is a multifaceted metabolic disorder associated with distinctive pathophysiolo...
Nutrient intake stimulates the secretion of the gastrointestinal incretin hormones, glucagon-like pe...
Incretins are gut hormones secreted by cells located in the small intestine in response to ingestion...
The potential influence of gastric emptying on the "incretin effect," mediated by glucose-dependent ...
The gastrointestinal tract releases several hormones in response to oral food intake and absorption....
individuals are capable of adjusting their insulin secretion to their actual insulin sensitivity, pe...
The incretin effect denominates the phenomenon that oral glucose elicits a higher insulin response t...
SummaryGut peptides, exemplified by glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotr...
Most researchers support the important role of incretins, particularly glucagon-like peptide-1 in im...
Incretin peptides, principally GLP-1 and GIP, regulate islet hormone secretion, glucose concentratio...
Type 2 diabetes mellitus is a worldwide health problem. Adequate glycemic control can help to preven...
The two incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like pepti...
Therapies targeting the action of incretin hormones have been under close scrutiny in recent years. ...
Gastric bypass surgery (GBP), in addition to weight loss, results in dramatic remission of type 2 di...
Gastric bypass surgery (GBP), in addition to weight loss, results in dramatic remission of type 2 di...
Type 2 diabetes (T2D) is a multifaceted metabolic disorder associated with distinctive pathophysiolo...
Nutrient intake stimulates the secretion of the gastrointestinal incretin hormones, glucagon-like pe...
Incretins are gut hormones secreted by cells located in the small intestine in response to ingestion...
The potential influence of gastric emptying on the "incretin effect," mediated by glucose-dependent ...
The gastrointestinal tract releases several hormones in response to oral food intake and absorption....
individuals are capable of adjusting their insulin secretion to their actual insulin sensitivity, pe...
The incretin effect denominates the phenomenon that oral glucose elicits a higher insulin response t...
SummaryGut peptides, exemplified by glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotr...
Most researchers support the important role of incretins, particularly glucagon-like peptide-1 in im...
Incretin peptides, principally GLP-1 and GIP, regulate islet hormone secretion, glucose concentratio...
Type 2 diabetes mellitus is a worldwide health problem. Adequate glycemic control can help to preven...
The two incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like pepti...
Therapies targeting the action of incretin hormones have been under close scrutiny in recent years. ...
Gastric bypass surgery (GBP), in addition to weight loss, results in dramatic remission of type 2 di...
Gastric bypass surgery (GBP), in addition to weight loss, results in dramatic remission of type 2 di...