Synthesis and β-adrenergic properties of tetrahydronaphthalene analogs of dichloroisoproterenol

The tetrahydronaphthalene analogs 4 and 5 of DCI (3b) and of its N-unsubstituted derivative (3a) were synthesized and tested for their beta-adrenergic properties by means of both binding tests and functional tests. Compounds 4 and 5 proved to possess a good affinity for beta-adrenergic receptors accompanied by an appreciable beta-blocking activity, thus indicating that the formal insertion of a beta-blocking drug such as DCI into a tetrahydronaphthalene structure is able to provide compounds which still possess a beta-blocking activity