Catalytic Regiodivergent Kinetic Resolution of Allylic Epoxides: a New Entry to Allylic and Homoallylic Alcohols with High Optical Puriy

A novel regiodivergent kinetic resoln. of a series of allylic epoxides with alkylzinc reagents is described. Results demonstrate the potential of chiral copper-phosphoramidite catalysts for enantiomer differentiation of allylic epoxides, allowing a chiral catalyst-stereoregulated synthesis of cyclic allylic and homoallylic alcs. with high optical purities