The activity of a series of 1,3-dipropyl-xanthines bearing C8-cycloalkyl substituents as antagonists at A1 and A2 adenosine receptors is examined. Pharmacological results showed that the size of the 8-substituent is an important feature for response in activity of such class of antagonists. Among compounds 3-8, the 2-norbornyl analog 6 showed the best A1/A2 selectivity. A new route for the synthesis of 8-alkyl-substituted xanthines is presented. This method, consisting of a direct alkylation of the imidazole moiety through a radical mechanism reaction, was shown to be a more convenient strategy in comparison with the commonly employed synthetic schemes
Comparison of the affinity towards adenosine receptors of 2-phenyl-8-azaadenosines, bearing a lipoph...
The title compounds were prepared to evaluate their affinity towards adenosine A1 and A2 receptors. ...
New 9-methyladenines, bearing different bulky groups at the 8-position, were prepd. and their affini...
A new series of 8-(substituted-phenyl)xanthines have been synthesized and compounds were evaluated f...
The present paper describes the synthesis of a series of 8-(cyclopentyloxy)phenyl-xanthines and thei...
A new series of 1H-imidazol-1-yl substituted 8-phenylxanthine analogs has been synthesized to study ...
Based on a previous report that a series of 8-(phenoxymethyl)-xanthines may be promising leads for t...
A series of 8-substituted adenosine and theophylline-7-riboside analogues (28 and 9 compounds, respe...
The receptor binding affinity data to adenosine A(1) and A(2a) receptors of a wide series of 8-ethen...
7-β-D-Ribofuranosylxanthine, a previously unreported isomer of xanthosine, was prepared in four step...
The xanthines currently represent the most potent class of adenosine receptor antagonists. However, ...
A new series of 9-methyladenines, bearing different bulky groups at the 8-position, were prepared an...
The title compounds were prepared to evaluate their affinity towards adenosine A1 and A2 receptors. ...
The synthesis of a series of 9-ethyladenine derivatives bearing alkynyl chains in 2- or 8-position w...
Adenosine A1 receptors are attracting great interest as drug targets for their role in cognitive def...
Comparison of the affinity towards adenosine receptors of 2-phenyl-8-azaadenosines, bearing a lipoph...
The title compounds were prepared to evaluate their affinity towards adenosine A1 and A2 receptors. ...
New 9-methyladenines, bearing different bulky groups at the 8-position, were prepd. and their affini...
A new series of 8-(substituted-phenyl)xanthines have been synthesized and compounds were evaluated f...
The present paper describes the synthesis of a series of 8-(cyclopentyloxy)phenyl-xanthines and thei...
A new series of 1H-imidazol-1-yl substituted 8-phenylxanthine analogs has been synthesized to study ...
Based on a previous report that a series of 8-(phenoxymethyl)-xanthines may be promising leads for t...
A series of 8-substituted adenosine and theophylline-7-riboside analogues (28 and 9 compounds, respe...
The receptor binding affinity data to adenosine A(1) and A(2a) receptors of a wide series of 8-ethen...
7-β-D-Ribofuranosylxanthine, a previously unreported isomer of xanthosine, was prepared in four step...
The xanthines currently represent the most potent class of adenosine receptor antagonists. However, ...
A new series of 9-methyladenines, bearing different bulky groups at the 8-position, were prepared an...
The title compounds were prepared to evaluate their affinity towards adenosine A1 and A2 receptors. ...
The synthesis of a series of 9-ethyladenine derivatives bearing alkynyl chains in 2- or 8-position w...
Adenosine A1 receptors are attracting great interest as drug targets for their role in cognitive def...
Comparison of the affinity towards adenosine receptors of 2-phenyl-8-azaadenosines, bearing a lipoph...
The title compounds were prepared to evaluate their affinity towards adenosine A1 and A2 receptors. ...
New 9-methyladenines, bearing different bulky groups at the 8-position, were prepd. and their affini...