Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database

Bonora E
Capaldo B
Perin PC
Del Prato S
De Mattia G
Frittitta L
Frontoni S
Leonetti F
Luzi L
Marchesini G
Marini MA
Natali A
Paolisso G
Piatti PM
Pujia A
Solini A
Vettor R
Bonadonna RC

Open link

Publication date

January 2008

DOI

10.1016/j.numecd.2007.05.002

Publisher

Elsevier BV

Abstract

BACKGROUND AND AIMS: We evaluated whether hyperinsulinemia and/or insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. METHODS AND RESULTS: A database of non-diabetic Italian subjects has recently been set up using data from hyperinsulinemic euglycemic clamp studies carried out using the standard technique (40 mU per min per square meter of body surface area). In this database we evaluated the relationships between fasting plasma insulin (FPI), glucose metabolized during clamp (M) and plasma levels of triglycerides (TG), high density lipoprotein cholesterol (HDL-C), uric acid (UA) as well as blood pressure (BP) in non-diabetic subjects with fasting plasma glucose <6.1 ...