A new fluorimetric assay to measure cytotoxic T-lymphocyte activity against feline immunodeficiency virus envelope glycoprotein

Cytotoxic T lymphocytes (CTLs) are important effectors in host immune responses to intracellular pathogens and tumors and have been shown to play a critical role in the control of HIV infection ( [Koup et al., 1994] and [Rowland-Jones et al., 1997]). Efficient and accurate measurement of CTL activity is therefore important for the evaluation of cellular immune responses to viral infections and in assisting the design of immunotherapeutic interventions and vaccines