Malignant brain tumor is a lethal disease with currently available treatment options having a limited impact on outcome. Nevertheless, novel therapeutic approaches combined with genetic prediction of chemosensitivity have, in the last decade, significantly improved clinical benefit for the treated patients. The fine characterization of the MDR1 gene encoding for P-glycoprotein (MDR1-Pgp) in brain tumors may be a crucial determinant for evaluating the long-term efficiency of specific anti-cancer compounds. By using a very high specific monoclonal antibody, the MDR1-Pgp was immunodetected in 34 out of 43 grade IV, 6 out of 10 grade III, 4 out of 7 grade II, and 1 out 3 grade I brain tumors. MDR1-Pgp resulted hyper-expressed, both in vessels a...
P-glycoprotein (P-gp) is a transmembrane drug efflux pump encoded by the MDR-1 gene in humans. Most ...
Brain tumors, whether primary or secondary, have limited therapeutic options despite advances in und...
Resistance of tumor cells to several structurally unrelated classes of natural products, including a...
Abstract Background To investigate the mechanisms of multidrug resistance of brain tumors, to identi...
Primary brain tumours, and especially the most common form malignant gliomas, usually display a pron...
The expression of MDR1 gene was investigated in human solid tumors with respect to adriamycin resist...
Chemotherapy in glioma is poorly effective: the blood–brain barrier and intrinsic and/or acquired dr...
P-Glycoprotein (P-gp) is a 170-kDa transmembrane glycoprotein that works as an efflux pump and confe...
Primary brain neoplasms and metastases to the brain are generally resistant to systemic chemotherapy...
The expression of MDR1 gene was investigated in human solid tumors with respect to adriamycin resist...
Purpose: Breast cancer resistance protein (BCRP) is a half adenosine triphosphate (ATP)-binding cass...
Multidrug resistance (MDR) is characterized by the occurrence of cross-resistance to a broad range o...
Multidrug resistance (MDR) is characterized by the occurrence of cross-resistance to a broad range o...
textabstractAlthough, generally speaking, haematological malignancies are chemotherapy-responsive tu...
AbstractP-glycoprotein (P-gp), an active efflux pump of antitumor drugs, is strongly expressed in en...
P-glycoprotein (P-gp) is a transmembrane drug efflux pump encoded by the MDR-1 gene in humans. Most ...
Brain tumors, whether primary or secondary, have limited therapeutic options despite advances in und...
Resistance of tumor cells to several structurally unrelated classes of natural products, including a...
Abstract Background To investigate the mechanisms of multidrug resistance of brain tumors, to identi...
Primary brain tumours, and especially the most common form malignant gliomas, usually display a pron...
The expression of MDR1 gene was investigated in human solid tumors with respect to adriamycin resist...
Chemotherapy in glioma is poorly effective: the blood–brain barrier and intrinsic and/or acquired dr...
P-Glycoprotein (P-gp) is a 170-kDa transmembrane glycoprotein that works as an efflux pump and confe...
Primary brain neoplasms and metastases to the brain are generally resistant to systemic chemotherapy...
The expression of MDR1 gene was investigated in human solid tumors with respect to adriamycin resist...
Purpose: Breast cancer resistance protein (BCRP) is a half adenosine triphosphate (ATP)-binding cass...
Multidrug resistance (MDR) is characterized by the occurrence of cross-resistance to a broad range o...
Multidrug resistance (MDR) is characterized by the occurrence of cross-resistance to a broad range o...
textabstractAlthough, generally speaking, haematological malignancies are chemotherapy-responsive tu...
AbstractP-glycoprotein (P-gp), an active efflux pump of antitumor drugs, is strongly expressed in en...
P-glycoprotein (P-gp) is a transmembrane drug efflux pump encoded by the MDR-1 gene in humans. Most ...
Brain tumors, whether primary or secondary, have limited therapeutic options despite advances in und...
Resistance of tumor cells to several structurally unrelated classes of natural products, including a...