As the matrix metalloproteinases (MMPs) can be massively up-regulated in degenerative tissues and degrade the extracellular matrix, these key enzymes are promising targets for the therapy of cancer and other degenerative diseases. Here, we are presenting a series of new non-peptidic hydroxamate-based matrix metalloproteinase inhibitors, MMPIs, incorporating the iminodiacetic (IDA) hydroxamic acid scaffold, as mimics of truncated peptidic MMPIs. A series of alkylaryl and sulfonylaryl groups, on the IDA basic scaffold, was investigated with the aim of improving potency and selectivity against MMPs involved in degenerative diseases. The sulfonamide based IDA derivatives studied (compounds B1-B3) showed to be potent (nM range) against deep S1′ ...
A novel series of sulfone N-formylhydroxylamines (retrohydroxamates) have been investigated as matri...
Osteoarthritis (OA) is the leading cause of joint pain and disability in middle-aged and elderly pat...
α-Piperidine-β-sulfone hydroxamate derivatives were explored that are potent for matrix metalloprote...
The matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases involved in the d...
Matrix metalloproteinases (MMPs) constitute a family of zinc-dependent proteases involved in the ext...
Matrix Metalloproteinases (MMPs) are multidomain zinc endopeptidases which play a central role in de...
Matrix Metalloproteinases (MMPs) are a family of enzymes that are attracting growing interest as the...
Matrix Metalloproteinases (MMPs) are a family of enzymes that are attracting growing interest as the...
Matrix metalloproteinases (MMPs) are an important family of zinc-containing enzymes with a central r...
Matrix metalloproteinases (MMPs) are an important family of zinc-containing enzymes with a central r...
Starting from the observation that the CbzNH(CH2)2 side chain of the potent MMP-2/MMP-14 inhibitor, ...
Matrix Metalloproteinases (MMPs) are a family of enzymes that are attracting growing interest as the...
Osteoarthritis (OA) is the leading cause of joint pain and disability in middle-aged and elderly pat...
A new class of potent matrix metalloproteinase (MMP) inhibitors designed by structure-based optimiza...
In an effort to develop potent inhibitors of matrix metalloproteinases (MMPs), a bioinorganic approa...
A novel series of sulfone N-formylhydroxylamines (retrohydroxamates) have been investigated as matri...
Osteoarthritis (OA) is the leading cause of joint pain and disability in middle-aged and elderly pat...
α-Piperidine-β-sulfone hydroxamate derivatives were explored that are potent for matrix metalloprote...
The matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases involved in the d...
Matrix metalloproteinases (MMPs) constitute a family of zinc-dependent proteases involved in the ext...
Matrix Metalloproteinases (MMPs) are multidomain zinc endopeptidases which play a central role in de...
Matrix Metalloproteinases (MMPs) are a family of enzymes that are attracting growing interest as the...
Matrix Metalloproteinases (MMPs) are a family of enzymes that are attracting growing interest as the...
Matrix metalloproteinases (MMPs) are an important family of zinc-containing enzymes with a central r...
Matrix metalloproteinases (MMPs) are an important family of zinc-containing enzymes with a central r...
Starting from the observation that the CbzNH(CH2)2 side chain of the potent MMP-2/MMP-14 inhibitor, ...
Matrix Metalloproteinases (MMPs) are a family of enzymes that are attracting growing interest as the...
Osteoarthritis (OA) is the leading cause of joint pain and disability in middle-aged and elderly pat...
A new class of potent matrix metalloproteinase (MMP) inhibitors designed by structure-based optimiza...
In an effort to develop potent inhibitors of matrix metalloproteinases (MMPs), a bioinorganic approa...
A novel series of sulfone N-formylhydroxylamines (retrohydroxamates) have been investigated as matri...
Osteoarthritis (OA) is the leading cause of joint pain and disability in middle-aged and elderly pat...
α-Piperidine-β-sulfone hydroxamate derivatives were explored that are potent for matrix metalloprote...