Thrombospondin (TSP) is a M(r) 450,000 multifunctional matrix glycoprotein that interferes with tumor growth, angiogenesis, and metastasis. It has recently been shown that TSP expression is enhanced by the product of the p53 gene and that a down-regulation of TSP may be observed when alterations of the p53 protein occur. Moreover, a number of studies have demonstrated a regulatory activity of p53 on human vascular endothelial growth factor (VEGF), although additional investigations will be necessary to understand their relationship. In non-small cell lung carcinoma (NSCLC), neoangiogenesis, p53 alterations, and VEGF expression seem to have meaningful implications in the development and progression of this type of cancer. The aim of this stu...
The vascular endothelial growth factor (VEGF) has been shown to be strictly related to vascular perm...
Anti-angiogenic therapies are an important class of anti-cancer treatment drugs. However, their effi...
Angiogenesis is an essential requirement for the development, progression and metastasis of malignan...
Thrombospondin (TSP) is a M-r 450,000 multifunctional matrix glycoprotein that interferes with tumor...
Vascular endothelial growth factor (VEGF) is a cytokine that is involved in tumor angiogenesis. Wild...
Following up-regulation of an angiogenesis inhibitor by the wild-type p53 protein proven recently, w...
BACKGROUND: Thrombospondin-1 (TSP-1) is an extracellular matrix component glycoprotein, which is kno...
We have previously demonstrated that vascular count significantly increases in the preneoplastic les...
Microvessel density and thrombospondin-1 (TSP-1) expression were analysed in 42 non-small cell lung ...
Purpose : To evaluate interactions between expressions of tumor suppressor gene p53 and angiogenic f...
The aim of this study was to investigate the expression of p53 and bcl2 proteins in a series of 107 ...
[[abstract]]Thrombospondin (TSP)-2, a matricellular glycoprotein of the TSP family, regulates multip...
Thrombospondin (TSP-1) is a 450-kd adhesive glycoprotein that was initially discovered in platelets ...
Objective. Recently, new functions have been attributed to the p53 protein, particularly a prominent...
Tumor growth and metastasis require neovascularization which is a process of generating new capillar...
The vascular endothelial growth factor (VEGF) has been shown to be strictly related to vascular perm...
Anti-angiogenic therapies are an important class of anti-cancer treatment drugs. However, their effi...
Angiogenesis is an essential requirement for the development, progression and metastasis of malignan...
Thrombospondin (TSP) is a M-r 450,000 multifunctional matrix glycoprotein that interferes with tumor...
Vascular endothelial growth factor (VEGF) is a cytokine that is involved in tumor angiogenesis. Wild...
Following up-regulation of an angiogenesis inhibitor by the wild-type p53 protein proven recently, w...
BACKGROUND: Thrombospondin-1 (TSP-1) is an extracellular matrix component glycoprotein, which is kno...
We have previously demonstrated that vascular count significantly increases in the preneoplastic les...
Microvessel density and thrombospondin-1 (TSP-1) expression were analysed in 42 non-small cell lung ...
Purpose : To evaluate interactions between expressions of tumor suppressor gene p53 and angiogenic f...
The aim of this study was to investigate the expression of p53 and bcl2 proteins in a series of 107 ...
[[abstract]]Thrombospondin (TSP)-2, a matricellular glycoprotein of the TSP family, regulates multip...
Thrombospondin (TSP-1) is a 450-kd adhesive glycoprotein that was initially discovered in platelets ...
Objective. Recently, new functions have been attributed to the p53 protein, particularly a prominent...
Tumor growth and metastasis require neovascularization which is a process of generating new capillar...
The vascular endothelial growth factor (VEGF) has been shown to be strictly related to vascular perm...
Anti-angiogenic therapies are an important class of anti-cancer treatment drugs. However, their effi...
Angiogenesis is an essential requirement for the development, progression and metastasis of malignan...