Background: The aim of this study is to test the mediational role of Experiential Avoidance (EA) to explain the relation of coping styles with anxiety and depression symptomatology in patients with cancer. Methods. 50 patients with cancer (82% females; Mean age=50.7, SD=10.7, range=24-70) participated in the study. Patients completed: the Acceptance-and-Action-Questionnaire, the Mini-Mental-Adjustment-to-Cancer, and the Hospital-Anxiety-Depression-Scale. Hierarchical regression analyses were performed. Findings: EA completely mediates the effect of Cognitive Avoidance (CA) on anxiety scores. The results do not however support the mediational model for the Anxious Preoccupation (AP) style. Secondary analyses suggest that AP mediates...