Answer Set Programming (ASP) is a popular logic programming paradigm that has been applied for solving a variety of complex problems. Among the most challenging real-world applications of ASP are two industrial problems defined by Siemens: the Partner Units Problem (PUP) and the Combined Configuration Problem (CCP). The hardest instances of PUP and CCP are out of reach for state-of-the-art ASP solvers. Experiments show that the performance of ASP solvers could be significantly improved by embedding domain-specific heuristics, but a proper effective integration of such criteria in off-the-shelf ASP implementations is not obvious. In this paper the combination of ASP and domain-specific heuristics is studied with the goal of effectively solvi...