Glutamate (Glu) excitotoxicity plays a major role in amyotrophic lateral sclerosis (ALS) and elevated extracellular Glu levels were found in patients and animal models of the disease. Reduced astrocyte uptake was suggested as the main cause for increased Glu availability. On the basis of our experiments, we postulated that abnormal neurotransmitter release represents another source for elevated Glu. Indeed, we found that neuronal Glu release from spinal cord synaptosomes is abnormally high in the spinal cord of pre-symptomatic and symptomatic SOD1G93A mice, a widely used experimental model of ALS, under resting conditions and upon exposure to different stimuli able to induce Glu exocytosis, including KCl depolarization, ionomycin, hypertoni...
Glutamate transporter proteins appear crucial to controlling levels of glutamate in the central nerv...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder due to loss of upper and l...
Glutamate (Glu)-mediated excitotoxicity is a major cause of amyotrophic lateral sclerosis (ALS) and ...
Abnormal Glu release occurs in the spinal cord of SOD1G93A mice, a transgenic animal model for human...
Abnormal Glu release occurs in the spinal cord of SOD1(G93A) mice, a transgenic animal model for hum...
Abstract Amyotrophic lateral sclerosis is a progressive and fatal neurodegenerative disease, involv...
Abstract Amyotrophic lateral sclerosis is a progressive and fatal neurodegenerative disease, involvi...
Astrocytes can be found between the vascular and neuronal elements of the central nervous system, wh...
Glutamate-mediated excitotoxicity plays a major role in the degeneration of motor neurons in amyotro...
Glutamate is one of the most prevalent neurotransmitters released by excitatory neurons in the centr...
The release of [3H]d-aspartate ([3H]d-ASP) or [3H]GABA evoked by glycine and that of [3H]d-ASP or [3...
Several causes have been suggested to contribute to amyotrophic lateral sclerosis (ALS) aetiology an...
Several neurodegenerative disorders involve impaired neurotransmission, and glutamatergic neurotrans...
Modifications in glutamate homeostasis together with gliosis and release of inflammatory mediators a...
The impact of synaptic vesicle endo-exocytosis on the trafficking of nerve terminal heterotransporte...
Glutamate transporter proteins appear crucial to controlling levels of glutamate in the central nerv...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder due to loss of upper and l...
Glutamate (Glu)-mediated excitotoxicity is a major cause of amyotrophic lateral sclerosis (ALS) and ...
Abnormal Glu release occurs in the spinal cord of SOD1G93A mice, a transgenic animal model for human...
Abnormal Glu release occurs in the spinal cord of SOD1(G93A) mice, a transgenic animal model for hum...
Abstract Amyotrophic lateral sclerosis is a progressive and fatal neurodegenerative disease, involv...
Abstract Amyotrophic lateral sclerosis is a progressive and fatal neurodegenerative disease, involvi...
Astrocytes can be found between the vascular and neuronal elements of the central nervous system, wh...
Glutamate-mediated excitotoxicity plays a major role in the degeneration of motor neurons in amyotro...
Glutamate is one of the most prevalent neurotransmitters released by excitatory neurons in the centr...
The release of [3H]d-aspartate ([3H]d-ASP) or [3H]GABA evoked by glycine and that of [3H]d-ASP or [3...
Several causes have been suggested to contribute to amyotrophic lateral sclerosis (ALS) aetiology an...
Several neurodegenerative disorders involve impaired neurotransmission, and glutamatergic neurotrans...
Modifications in glutamate homeostasis together with gliosis and release of inflammatory mediators a...
The impact of synaptic vesicle endo-exocytosis on the trafficking of nerve terminal heterotransporte...
Glutamate transporter proteins appear crucial to controlling levels of glutamate in the central nerv...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder due to loss of upper and l...
Glutamate (Glu)-mediated excitotoxicity is a major cause of amyotrophic lateral sclerosis (ALS) and ...