Circulating Biomarkers in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Patients
- Pescini, Francesca
- Donnini, Ida
- Cesari, Francesca
- Nannucci, Serena
- Valenti, Raffaella
- Rinnoci, Valentina
- Poggesi, Anna
- Gori, Anna Maria
- Giusti, Betti
- Rogolino, Angela
- Carluccio, Alessandra
- Bianchi, Silvia
- Dotti, Maria Teresa
- Federico, Antonio
- Balestrino, Maurizio
- Adriano, Enrico Giovanni
- Abbate, Rosanna
- Inzitari, Domenico
- Pantoni, Leonardo
Publication date
January 2017
DOI Publisher
Elsevier BV ISSN
1052-3057 Citation count (estimate)
2Abstract
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited cerebral microangiopathy presenting with variable features, including migraine, psychiatric disorders, stroke, and cognitive decline and variable disability. On neuroimaging, CADASIL is characterized by leukoencephalopathy, multiple lacunar infarcts, and microbleeds. Previous studies suggest a possible role of endothelial impairment in the pathogenesis of the disease
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