This dissertation presents the theoretical study of two-component fermionic gases. It firstly studies the BCS-BEC crossover for the system of the two-component fermionic gas in optical lattices. If the system were loaded into deep three-dimensional optical lattices, a tight-binding model with the lowest band is applicable. If the band is more than half-filled and by increasing the attractive interactions, then there exists a novel crossover, from a paired BCS superfluid to a BEC of holes, back to the BCS superfluid, and finally to a conventional BEC regime of diatomic molecules. If the band is less than half-filled, the crossover is similar to that without optical lattices. If the band is fully filled, a quantum phase transition from band i...