Tumor infiltrating lymphocyte (TIL) and CD8+ cells in TNBC: new prognostic markers

Triple negative breast cancer (TNBC) stands out for a remarkable morphological and biological heterogeneity associated with a high propensity for systemic metastases and poor survival in comparison with the different subtype of breast cancer. The efforts to adopt specific target therapies are complicated by the difficulty to identify representative and reproducible markers. Recently, there is increasing evidence of the role of tumorinfiltrating lymphocytes (TILs) in this subtype of breast cancer in terms ofimproving disease-free (DFS) and overall survival (OS) rates