Objectives: Bisphosphonates (BPs) are drugs clinically used in resorptive diseases. It was already proved that some clinically relevant BPs can inhibit a class of enzymes called matrix metalloproteinases (MMPs), required during tissue remodelling. Combining the arylsulfonamide function with the bisphosphonic group, several compounds were synthesized to obtain selective inhibitors of MMPs. The aim of the present study was to compare the effect of zoledronic acid (ZA), the most potent bisphosphonate available as therapy, with new sulfonamide containing BPs in an in vitro model of human gingival fibroblasts (HGFs). Materials and methods: Western blot was used to measure procollagen I, β1 integrin MMP-8 and MMP-9, phase contrast and MTT for cel...
Bisphosphonates (BP) like Zometa (ZA) are widely used to treat complications of bony metastases in c...
The aim of this study was to elucidate the role of fibroblasts in bisphosphonate-related osteonecros...
Bisphosphonate-induced osteonecrosis has been related to the cytotoxicity of these drugs on oral muc...
Objectives: Bisphosphonates (BPs) are drugs clinically used in resorptive diseases. It was already p...
Periodontitis is an inflammatory disease caused by anaerobic bacteria, including Porphyromonas gingi...
Bisphosphonate-induced osteonecrosis has been related to the cytotoxicity of these drugs on oral muc...
Background: Osteonecrosis of the jaws is recognised as a serious complication for patients receiving...
Background: Bisphosphonate related osteonecrosis of the jaw (BRONJ) is a widely recognised dental si...
Abstract Osteonecrosis of the jaw is an adverse effect of bisphosphonates. While the etiopathogenesi...
Introduction: Patients treated with nitrogen-containing bisphosphonates, such as zoledronic acid (ZA...
Amino-bisphosphonates (N-BPs) are widely used to treat a great variety of clinical conditions involv...
INTRODUCTION: Patients treated with nitrogen-containing bisphosphonates, such as zoledronic acid (ZA...
Bisphosphonate drugs are well known to inhibit osteoclastic activity and have been proposed for the ...
Osteonecrosis of the jaw (ONJ) has been associated with bisphosphonate (BP) treatment of Paget’s di...
The mevalonate pathway (MVP) and the anti-angiogenic effect of bisphosphonates have been shown to pl...
Bisphosphonates (BP) like Zometa (ZA) are widely used to treat complications of bony metastases in c...
The aim of this study was to elucidate the role of fibroblasts in bisphosphonate-related osteonecros...
Bisphosphonate-induced osteonecrosis has been related to the cytotoxicity of these drugs on oral muc...
Objectives: Bisphosphonates (BPs) are drugs clinically used in resorptive diseases. It was already p...
Periodontitis is an inflammatory disease caused by anaerobic bacteria, including Porphyromonas gingi...
Bisphosphonate-induced osteonecrosis has been related to the cytotoxicity of these drugs on oral muc...
Background: Osteonecrosis of the jaws is recognised as a serious complication for patients receiving...
Background: Bisphosphonate related osteonecrosis of the jaw (BRONJ) is a widely recognised dental si...
Abstract Osteonecrosis of the jaw is an adverse effect of bisphosphonates. While the etiopathogenesi...
Introduction: Patients treated with nitrogen-containing bisphosphonates, such as zoledronic acid (ZA...
Amino-bisphosphonates (N-BPs) are widely used to treat a great variety of clinical conditions involv...
INTRODUCTION: Patients treated with nitrogen-containing bisphosphonates, such as zoledronic acid (ZA...
Bisphosphonate drugs are well known to inhibit osteoclastic activity and have been proposed for the ...
Osteonecrosis of the jaw (ONJ) has been associated with bisphosphonate (BP) treatment of Paget’s di...
The mevalonate pathway (MVP) and the anti-angiogenic effect of bisphosphonates have been shown to pl...
Bisphosphonates (BP) like Zometa (ZA) are widely used to treat complications of bony metastases in c...
The aim of this study was to elucidate the role of fibroblasts in bisphosphonate-related osteonecros...
Bisphosphonate-induced osteonecrosis has been related to the cytotoxicity of these drugs on oral muc...