New titanocene derivatives with high antiproliferative activity against breast cancer cells
- SATURNINO, CARMELA
- Sirignano E.
- Botta A.
- Sinicropi M. S.
- Caruso A.
- Pisano A.
- Lappano R.
- Maggiolini M.
- Longo P.
DOIAbstract
The synthesis and characterization of some new titanocene-complexes, having a ethenyl-phenoxide or a benzyl group as substituents of the cyclopentadienyl rings, are reported. The synthesized compounds have been evaluated for their cytotoxic potential against two human breast cancer cell lines, that is: MCF7 and SkBr3. Most of these compounds have shown significant cytotoxic effects, compared to cisplatin, in MTT-based cell tests
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