Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010
- Colafigli, M.
- Torti, C.
- Trecarichi, E.
- Albini, L.
- Rosi, A.
- Micheli, V.
- Manca, N.
- Penco, G.
- Bruzzone, B.
- Punzi, G.
- Corsi, P.
- Parruti, G.
- Bagnarelli, P.
- Monno, L.
- Gonnelli, A.
- Cauda, R.
- Di Giambenedetto, S.
- Mancuso, S.
DOIAbstract
Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-na\uefve HIV-1-infected patients, with a genotypic resistance test (GRT) performed 646months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs. B subtype predicted lower odds of TDR. \ua9 2012 The Authors. Clinical Microbiology and Infection \ua9 2012 European Societ...
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