Cost evaluation of irinotecan-related toxicities associated with the UGT1A1*28 patient genotype
- Roncato, Rossana
- Cecchin, E
- Montico, M
- De Mattia, E
- Giodini, Luciana
- Buonadonna, A
- Solfrini, V
- Innocenti, F
- Toffoli, G.
DOIAbstract
The adoption of a pre-emptive UGT1A1*28 genotyping to increase irinotecan safety in clinical practice is still limited. This is the first actual study of costs associated to the management of irinotecan-related toxicity, and their association with UGT1A1*28 genotype. A retrospective analysis of the cost of toxicity management was conducted on 243 metastatic colorectal cancer patients enrolled in a clinical trial and treated with standard of care FOLFIRI. The mean predicted cost per patient was higher for *28/*28 (4,886\u20ac), versus *1/*1 (812\u20ac), (regression coefficient 1.79, 95%CI=1.31-2.28; P<0.001) and for *1/*28 (1,119\u20ac) versus *1/*1 (regression coefficient 0.32, 95%CI=0.04-0.60; P=0.024). This is consistent with a different ...
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